Carbohydrate antigen 125 (CA125) or MUC16 (the gene encoding MUC16) is a cell surface glycoprotein1 that is commonly used as a tumor marker for the diagnosis and prognosis of ovarian cancer (OC).2 OC is the seventh most common cancer and the eighth worldwide main cause of mortality among women.3,4 MUC16 effectiveness in diagnosing early stages of OC is limited due to its low sensitivity. This evidence concerns the gene MUC16 and cancer.