TGFB1 and cancer: Despite these features, it is suggested that the promotion of allo- and xeno-reactive response is less after the injection of allogeneic and xenogeneic Exos in light of low levels of exosomal recognition elements like MHC-1 when compared to cellular counterparts.12 Likewise, the existence of anti-inflammatory factors like IL-10 and TGF-β can also diminish the activity of phagocyte cells.11 In this study, we did not observe adverse clinical outcomes in the rats that received normal or cancer xenogeneic Exos.