Hodgkin’s lymphoma is further subdivided into non-classical Hodgkin’s lymphoma and classic Hodgkin’s lymphoma.1,3,4 NHL includes numerous subtypes, with the most prevalent being diffuse large B-cell lymphoma (DLBCL) (25-30%), accounting for over 30% of B-NHL cases.5-8 In contrast to Hodgkin’s lymphoma, 90% of cases belong to the NHL category, which includes B-cell NHL (B-NHL) expressing markers CD20, CD19, or CD22, T-cell NHL (T-NHL) expressing CD3, CD4, or CD8, and natural killer (NK)/T cell NHL expressing CD56.9-11. The gene discussed is CD22; the disease is diffuse large B-cell lymphoma.