BACE1 and Alzheimer disease: In addition, studies have shown that a single mRNA can be regulated by multiple miRNAs.9,10 These processes include metabolism, neurodevelopment, neuroplasticity, and apoptosis, which are fundamental to the functioning of the nervous system.11 Several studies have shown the correlation between miR-125b and mir-107 expression changes and oxidative stress.12-14 The expression of miR-107 was significantly decreased in patients with AD, whereas the expression of beta-secretase 1 (BACE1) was significantly increased.