LEP and central nervous system cancer: It seems that these effects are associated with the alteration in the affinity of LDP 14 to the shot isoform receptors resulting in the recycling and relaxation time of the receptor after attaching to the peptide.75,76 The high rate of Lep 30 and LDP 14 internalization in human U87 glioma cells indicates the overexpression of ObRs in these cells.54 To validate the specificity of the designed peptide in human cells, we also incubated the rat C6 glioma cells labeled LDP 14.