BCL2 and neoplasm: In support of the above finding, the ratio between BAX and BCL-2 expression, indicating a cell death switch, determines the survival or death of cells in response to stimulators of apoptosis, leading to enhanced cell death and reduced tumor incidence.47,48 It is very important to increase the expression of BAX/BCL-2 genes in CCSCs.49 Cell proliferation was assessed through the examination of the gene expression levels of KI-67.