In several mouse models of hypertension, Filer et al. discovered that while DEL-1 upregulation did not lead to differential expression of pro-metalloproteinase-2 (Pro-MMP-2) in the aorta and heart, it did inhibit αvβ3 integrin-dependent activation of Pro-MMP-2 in isolated mouse and human aortas. The gene discussed is MMP2; the disease is hypertensive disorder.