The univariate MR analysis of these 91 inflammatory proteins with COPD revealed positive causal relationships for CXCL10 (OR = 1.093, 95% CI 1.034–1.155; p = 0.001), EN-RAGE (OR = 1.117, 95% CI 1.041–1.198; p = 0.002), CD6 (OR = 1.064, 95% CI 1.022–1.107; p = 0.002), STAMPB (OR = 1.104, 95% CI 1.012–1.205; p = 0.025), and CXCL6 (OR = 1.062, 95% CI 1.015–1.112; p = 0.008). Here, CXCL6 is linked to chronic obstructive pulmonary disease.