ALB and Cognitive impairment: For instance, a comprehensive seven-year retrospective cohort study involving 1,800 subjects demonstrated that reduced serum albumin concentrations independently raise the risk of mild cognitive impairment (MCI) in older adults (7), though another study found that serum albumin concentrations did not differ according to cognitive function in 540 older cognitively normal adults from the single-center Conselice Study of Brain Aging (8).