PRDM16 and obesity due to melanocortin 4 receptor deficiency: Hence, this study delves into LGZG’s role in fat browning by examining its effect on lipid accumulation and mitochondrial function in 3T3-L1 adipocytes, as well as its capacity to trigger the browning program through the miR-27b/PRDM16 pathway, aiming to elucidate its role in promoting metabolic health and combating obesity.