KLF4 and myocardial infarction: Dongmei et al. found that the overexpression of KLF4 can alleviate myocardial infarction injury and improve cardiac function in mice (Dongmei et al., 2015), suggesting KLF4 has a cardiac protective effect (Qian et al., 2019; Xi et al., 2022; Tao et al., 2023).