CD4 and neoplasm: In contrast to the published reports (55, 56), analysis of tumor-bearing zDC-DTR mice showed that the transient depletion of cDC1 and cDC2 resulted in the delayed growth of tumors and the enhanced survival rates possibly due to the drastic reduction of CD4+Foxp3+ Treg cells and maintenance of TH cells in TdLNs (50).