Furthermore, tumor-bearing CD11c:DTA mice showed an enhanced expression of TIM-3 on CD4+ T cells and PD-1 and TIM-3 on CD8+ T cells in Spl as compared with those obtained from tumor-bearing WT mice (Figures 2I–L; Supplementary Figures 18E, F in the Supplementary Material). Here, HAVCR2 is linked to neoplasm.