HAVCR2 and neoplasm: However, tumor-infiltrating CD4+ tumor-infiltrating lymphocytes (TILs) and CD8+ TILs obtained from tumor-bearing WT mice not only had the marked proportions of CD4+CD44+CD62L− T cell subset and CD8+CD44+CD62L− T cell subset, which function as effector memory T (TEM) cells (44), but also expressed PD-1, TIM-3, and LAG-3 (Figures 2A–D; Supplementary Figures 18A, B in the Supplementary Material).