MPPE1 and neoplasm: While the transient depletion of cDC1 and cDC2 in zDC (Zbtb46)-DTR mice or CD11c+ DCs in CD11c-DTR mice reportedly reduced the effect of tumor vaccination to enhance the survival rates of tumor-bearing mice and to inhibit the development of tumor (55, 56), their transient depletion had little or no effect on the tumor growth (56).