While the development of CD4+Foxp3+RORγt+ Treg cells and their role in the regulation of anti-tumor immunity as well as their relation to the intestinal CD4+Foxp3+RORγt− Treg cells remain unclear, it is possible that CD4+Foxp3+RORγt− Treg cells convert into CD4+Foxp3+RORγt+ Treg cells in the milieu of the abundance of various proinflammatory cytokines under the constitutive absence of CD11chi DCs (14), and they suppress anti-tumor functions of CD4+ Teff cells and CTLs in lymphoid tissues. Here, CD4 is linked to neoplasm.