ZBTB46 and neoplasm: Therefore, the transient depletion of CD11c+ DCs in CD11c-DTR mice or cDC1 and cDC2 in zDC (Zbtb46)-DTR mice may be insufficient for the induction of the breakdown of the tumor immunosurveillance to enhance the development of tumor, whereas their transient depletion could be sufficient for impairment of the enhanced anti-tumor immune response triggered by tumor vaccination.