Furthermore, the intestinal CD4+Foxp3+RORγt+ Treg cells induced by gut microbiota have been shown to contribute to the suppression of gut inflammation (64, 65), the inhibition of TH2-driven defense against helminths and TH2-associated colitis (66), and the inhibition of intestinal TH2-associated allergy (67). Here, FOXP3 is linked to allergic disease.