We used a 1-Chloro-2,4-dinitrobenzene (DNCB)-induced AD mouse model with LECT2 knockout (KO) and wild-type (WT) mice, and a TNF-α/IFN-γ-induced human immortalized keratinocytes (HaCaT) cell model to simulate AD condition. Here, LECT2 is linked to Alzheimer disease.