In contrast, in the AD group, the absence of the LECT2 gene resulted in relatively decreased mRNA levels of TNF-α, IL-1β, IL-4, IL-6, and IL-13 in DNCB-induced AD-like skin lesions, and relatively reduced protein levels of TNF-α, IgE, IL-4, and IL-13 in DNCB-induced mice serum. Here, IGHE is linked to Alzheimer disease.