The pro-cancer role of IL-37 in gastric cancer is further sustained from multivariate analysis, which provides a more reliable prediction than univariate, showing that while the depth of invasion (T1-2 vs T3-4) and stage (I-II vs III-IV) were significant under univariate analysis, IL-37 expression (low vs high) remained significant under multivariate analysis and was the most reliable predictor for overall survival and progression free survival using multi-variate analysis. This evidence concerns the gene IL37 and cancer.