(36) reported that the serum levels of citrullinated histone 3 (citH3) were increased in a dextran sulfate sodium-induced ulcerative colitis murine model, while Cl-amidine (a PAD4 inhibitor) or PAD4 genetic knockout successfully alleviated the clinical colitis index, intestinal inflammation, and barrier dysfunction. This evidence concerns the gene PADI4 and colitis.