By directly inhibiting suppressive cytokines such as IL-10, IL-35, and transforming growth factor beta (TGF-beta), as well as indirect inhibitory mechanisms such as the subversion of dendritic cells towards more immune regulatory phenotypes, the depletion of local IL-2 (a key T cell growth factor), a suppressive tumor microenvironment is established. The gene discussed is IL2; the disease is neoplasm.