Study showed that the perforin+ percentage of PD-1(+) TIM-3 (+) CD8 TIL in ovarian cancer was lower than that of PD-1(-) TIM-3(-) and PD-1(+) TIM-3(-) CD8TIL; the granzyme B+ percentage of PD-1+TIM-3+CD8TIL in OC was also lower than that of PD-1(-) TIM-3(-) and PD-1(+) TIM-3(-) CD8 TIL. This evidence concerns the gene CD8A and ovarian cancer.