PIK3R3 and hepatocellular carcinoma: The Chinese herbal decoction Kuan-Sin-Yin (KSY) reduces the expression of CCL2, which is associated with cell migration, and downregulates the mRNA levels of phosphoinositide-3-kinase regulatory subunit 3 (PIK3R3) and CEA cell adhesion molecule 1 (CEACAM1), thereby inhibiting the migration and invasion of HCC cells (111).