I/R causes an increase in CXCL5 levels in the cerebrospinal fluid of ischemic stroke patients, which in turn leads to damage of human brain microvascular endothelial cells and blood-brain barrier disruption, and CXCL5 levels are positively correlated with the degree of early cerebral nerve injury (Yu et al., 2021b). The gene discussed is CXCL5; the disease is ischemic stroke.