CCL11 negatively regulates neurogenesis in aged mice under physiological conditions, significantly exacerbates brain injury in adult stroke mice, and promotes neural regeneration in adolescent mice (Lieschke et al., 2019).Meaghan Roy-O 'Reilly found a significant increase in CCL11 levels in young and aged mice 24 hours after experimental stroke, yet found a significant decrease in CCL11 levels in ischemic stroke patients 24 hours after stroke. Here, CCL11 is linked to ischemic stroke.