Bone marrow stromal cells shift microglia cell type from pro-inflammatory to anti-inflammatory in rats with middle cerebral artery occlusion by secreting CX3CL1, which would provide clues for the treatment of ischemic stroke-related diseases (Bai et al., 2021a).Lieschke S found that intraperitoneal injection of CCL11 significantly exacerbated acute brain injury and significantly impaired post-stroke neurological recovery in adult stroke mice, and administration of CCL11 inhibitors resulted in an increase in microglia and a reversal of these effects. The gene discussed is CCL11; the disease is Stroke.