During the CI/R phase, CXCL5 recruits inflammatory cytokines at sites of cerebral ischemia and disrupts cerebral vasculature; activated cerebral vasculature can exacerbate cerebral neuronal injury by expressing CXCL13; meanwhile, XCL-1 and CCL2/MCP-1 promote neuronal apoptosis. The gene discussed is CXCL5; the disease is brain ischemia.