TNF and cancer: DEGs of low-score group were obviously enriched in tumor immunosuppressive microenvironment, such as Th1 and Th2 cell differentiation, TNF signaling pathway, Cytokine-cytokine receptor interaction, PD-L1 expression and programmed death-1 (PD-1) checkpoint pathway in cancer, TGF-beta signaling pathway and negative regulation of immune response (Figures 3A, B).