Moreover, TSPAN4 is upregulated in mouse models of spontaneous myocardial infarction (MI) and induced MI, suggesting that TSPAN4 and migrasomes may be potential targets of macrophages involved in atherosclerosis (Lin et al., 2019; Zheng et al., 2023a; Zheng et al., 2023b). This evidence concerns the gene TSPAN4 and myocardial infarction.