Baesd on the results of metagenomic data in diabetes and the multiomics analyses in impaired glucose tolerance, we found that decreased CARN and TUDCA, the metabolites derived from GM, reduced the inhibition on the synthesis of IGFBP-3 and the expression of IL-6 to result in hyperglycemia and related vasculopathy. This evidence concerns the gene IGFBP3 and vascular disorder.