IL6 and plasma cell myeloma: Additionally, IL-6 plays a critical role in various cellular processes, including the maturation of megakaryocytes into platelets, the activation of hematopoietic stem cells, and the differentiation and proliferation of multiple cell types, such as osteoblasts, keratinocytes, glomerular membrane cells, myeloma, and plasmacytoma cells (Akbari and Hassan-Zadeh, 2018; Robinson et al., 2020).