EPO and preeclampsia: This aligns with prior research indicating that endothelial damage-induced platelet activation leads to an increase in immature platelets and platelet turnover, culminating in elevated P-LCR and PDW in preeclamptic pregnant women.11,19,32 Furthermore, placental hypoxia in pregnant women with preeclampsia can stimulate the release of erythropoietin by the kidney and liver, triggering the production of large megakaryocytes in the bone marrow, thereby influencing platelet parameters.20