Lately it has been described that IL-2, a potent Treg cells inductor, crucial for their survival, normalized anxiety and depressive-like behavior in a CUS model, also normalizing neurotransmitter concentrations and cytokines IL-17, tumor growth factor (TGF)-β and IL-6 in the hippocampus (Huang et al., 2022). Here, TGFB1 is linked to Anxiety.