*Data presented as Mean ± SD, paired t test. **Data presented as Mean ± SD, Wilcoxon test. DOR: Diminished ovarian reserve, POI: Premature ovarian insufficiency, IVA: In vitro activation, AMH: Anti-Mullerian hormone, AFC: Antral follicle count, E2: Estradiol, LH: Luteinizing hormone, FSH: Follicle-stimulating hormone. The gene discussed is PLOD1; the disease is ovarian dysfunction.