Since BAT and T3 (through conversion of T4) are both activated when the body is exposed to cold temperatures, hypothyroidism is expected to influence BAT [28]. However, this study of eight patients with thyroid cancer in both hypothyroid and thyrotoxic conditions did not show a significant short-term relationship (two to four weeks) between thyroid hormone levels and BAT mass [28]. The gene discussed is TG; the disease is hypothyroidism.