However, tumor site analysis revealed some differences, with rectal tumors being more common in high S100A14 expression cases (35.00%) compared to low expression cases (five, 13.16%), albeit with a P-value of 0.0857. Tumor size did not differ significantly between the groups (P = 0.9860), nor did the presence of tumors in the right or left colon and transverse colon. Here, S100A14 is linked to rectal neoplasm.