To investigate the transcriptomic effect of androgen and 11-oxyandrogen signaling on endometrial cancer cells, we performed mRNA sequencing upon 48h incubation with 10 nM DHT, 10 nM 11KDHT or ethanol as control of two model cell lines, namely Ishikawa, which expressed AR (Supplementary Figure 2A) and RL95-2, which was the most efficient in metabolizing androgen and 11-oxyandrogen precursors and expressed low AR levels (Figures 1, 2). Here, AR is linked to endometrial cancer.