As a result of SNP filtering, 18, 18, 18,18,5,17,17,17,17,17 and 4 SNPs were included for GD, HT, hypothyroidism, hyperthyroidism, TC, TSH, TRH, THRα, TP, TG and TBG, respectively, in final analysis (Supplementary Table S2). The gene discussed is TRH; the disease is hypothyroidism.