As a result of SNP filtering, 18, 18, 18,18,5,17,17,17,17,17 and 4 SNPs were included for GD, HT, hypothyroidism, hyperthyroidism, TC, TSH, TRH, THRα, TP, TG and TBG, respectively, in final analysis (Supplementary Table S2). This evidence concerns the gene TRH and hyperthyroidism.