We found that age (B = 0.048; 95% CI 0.03 to 0.07; P<0.001), duration of DM (B = 0.065; 95% CI 0.04 to 0.09; P<0.001), cholesterol baseline (B=-0.259; 95% CI-0.42 to -0.1; P=0.002), HbA1c baseline (B = -0.834; 95% CI -0.93 to -0.74; P<0.001), FBG baseline(B= -0.143; 95% CI -0.19 to -0.09; P<0.001) and insulin use (B = 0.932; 95% CI 0.54 to 1.33; P<0.001) were significantly associated with HbA1c change (Table S1: in Supplementary Files). Here, INS is linked to diabetes mellitus.