Second, research reports have indicated that the expression patterns of some cytokines (IL-2, IL-5, IL-6, etc.)are significantly different between the MRL/lpr mouse model and clinical patients with LN (69, 70), suggesting that the MRL/lpr mouse model, as one of the models of spontaneous lupus, may not fully simulate the whole pathophysiological process of human LN disease. The gene discussed is IL6; the disease is systemic lupus erythematosus.