In addition, the core genes (including CCNA2, TOP2A, CDT1, HSPA8, and TSG101) were also enriched in cell cycle regulatory signaling pathways, which was consistent with the recent findings of enhanced cell cycle signaling pathways in patients with LN and SLE revealed by high-pathway sequencing (65, 66). Here, CDT1 is linked to systemic lupus erythematosus.