The binding of IL-17 to IL-17R on tumor cells activates downstream molecules, including transcription factors (NF-κB, STAT, and AP-1), kinases (MAPK and HER1), matrix metalloproteinases (MMPs), and anti-apoptotic proteins (Akt, Erk, mTOR, Bcl-2, and Bax). This evidence concerns the gene BAX and neoplasm.