The results showed that the SNV frequencies of TCF4, TCF3, and TCF7 were highest in UCEC (42% for TCF4, 14% for TCF3 and TCF7), followed by skin cutaneous melanoma (SKCM) (38% for TCF4, 10% for TCF3, and 4% for TCF7) and colon adenocarcinoma (COAD) (13% for TCF4, 10% for TCF3, and 8% for TCF7). This evidence concerns the gene TCF7 and cutaneous melanoma.