NFKB1 and cancer: In addition, our research was not able to include in-depth experiments on the mechanism of the pro-tumorigenic role of TCF-3 in cancer and the role of the IL-17/TCF-3/NF-κB/MMP2 axis in regulating aberrant malignancy status, which might reflect potential replicability issues in clustering patients with differential TCF-3 infiltration statuses.