Otherimportant differentially methylated genes after TPHP exposure includedSOX6 [SRY (sex determining region Y)-box 6], which is a transcriptionfactor that has recently been reported to contribute to the developmentalorigins of obesity, as shown using human, mouse cell culture, andzebrafish larvae potentially by regulating PPAR γ, C/EBP, andWNT signaling pathways.49 Further, glycogensynthase kinase 3 beta (GSK3β) is a serine/threonine kinasethat plays a key role in various cellular processes, including development,cell proliferation, and signal transduction. The gene discussed is GSK3B; the disease is obesity due to melanocortin 4 receptor deficiency.