Though the significance is not clear, the two top upregulated prostate cancer ERVs are situated in a chr22 region that has been linked to chromosomal rearrangements HERV-K11 LTR5Hs 22q11.21 and HERV-K HML-2 LTR5B 22q11.23 [161]. This evidence concerns the gene CLEC10A and prostate carcinoma.