Moreover, TRIM7 was found to be expressed at higher levels in tissues of patients with osteosarcoma, and its increased expression correlates with poor prognosis in these patients; mechanistically, TRIM7 positively regulates cell migration and invasiveness of osteosarcoma cells by ubiquitinating the breast cancer metastasis suppressor (BRMS1) at the lysine K184 [30]. This evidence concerns the gene BRMS1 and osteosarcoma.