From the same protein family of E3 ligases, MARCH1 and MARCH2 have similar anti-Env activities to MARCH8; unlike MARCH8, MARCH1 and MARCH2 are stimulated by type I IFNs, and MARCH2 is upregulated by HIV-1 infection alone [604,605,606]. The gene discussed is MARCHF1; the disease is HIV-1 infection.