CXCL16 and type 2 diabetes mellitus: Considering that CXCL16 levels are elevated in T2DM patients compared to healthy individuals [237,238] and there is a marked upregulation of serum CXCL16 levels in β-cells in a T1DM model [232], we postulate that there will be increased ADAM10 and/or ADAM17 levels under such conditions.