The transmembrane receptor protein tyrosine kinase signal pathway, protein autophosphorylation, PI3K-Akt signal pathway, fluid shear stress and atherosclerosis, chemical carcinogen-receptor activation, human cytomegalovirus infection, microRNA in cancer, and endocrine resistance and Alzheimer’s disease were also identified. Here, AKT1 is linked to early-onset autosomal dominant Alzheimer disease.