AKT1 and early-onset autosomal dominant Alzheimer disease: A total of 140 KEGG enrichment analysis items were obtained, with a higher degree of aggregation in cancer signaling pathways, proteoglycans in cancer, lipids and atherosclerosis, the PI3K-Akt signaling pathway, fluid shear stress and atherosclerosis, chemical carcinogenesis-receptor activation, human cytomegalovirus infection, microRNA in cancer, and endocrine resistance and Alzheimer’s disease (Figure 4).