Notably, the oxidative damage-related targets analyzed by the KEGG pathway enrichment were mainly involved in signaling pathways (HIF-1, IL-17, Thyroid hormone, and AGE-RAGE), cancer pathways (proteoglycans in cancer, PD-L1 expression and PD-1 checkpoint pathway in cancer, prostate cancer), herpesvirus and bacterial infection (kaposi sarcoma-associated herpesvirus infection, Human cytomegalovirus infection, salmonella infection), hepatitis B, lipid and atherosclerosis, and so on (Figure 5D). Here, CD274 is linked to bacterial infectious disease.