Punicic acid in pomegranate seeds has been found as a potential metabolite for reversing obesity-related hyperlipidemia and non-alcoholic fatty liver disease where the activation of the TLR4/MyD88/NF-κB and TLR4/IL-22/STAT3 signaling pathways were involved, considering that this compound is an effective nutraceutical ingredient for attenuating lipid metabolic disorders [29]. The gene discussed is TLR4; the disease is obesity due to melanocortin 4 receptor deficiency.