The induced expression of known rice hypoxia response genes, such as OsCIPK15 (CALCINEURIN B LIKE (CBL) INTERACTING PROTEIN KINASE), OsHIGD2 (HYPOXIA-INDUCED GENE DOMAIN 2), and ALCOHOL DEHYDROGENASE 2 (ADH2), also validated the occurrence of hypoxia during infection by M. oryzae [150]. The gene discussed is ADH4; the disease is infection.