The overactivation or constitutive activation of the Nrf2/ARE antioxidant system can contribute to a range of diseases, including multidrug-resistant cancers, autoimmune disorders, cardiovascular diseases, neurodegenerative conditions, fibrosis, and metabolic issues, by promoting tumor cell survival and resistance, disrupting immune homeostasis, and negatively impacting metabolic and neuronal functions [42,43,44,45]. This evidence concerns the gene NFE2L2 and neoplasm.