Activation of STING by endogenous cGAMP or cGAMP agonists mediates a type-I interferon (IFN-I) response that promotes the maturation and migration of dendritic cells, which in turn presents tumor-associated antigens on major histocompatibility complexes to activate CD8+ T cells for tumor-specific cell killing [194,195]. Here, CD8A is linked to neoplasm.