The antitumoral activity of anti-TF-NC-6300 was higher in mice bearing tumor xenografts with high TF expression (human gastric cancer 44As3 cells and human pancreatic cancer BxPC3 cells) compared with NC-6300 but in low-TF-expressing xenografts (human pancreatic cancer SUIT2 cells) both formulations showed similar activity, although with higher tumor accumulation of anti-TF-NC-6300. The gene discussed is TF; the disease is familial pancreatic carcinoma.