Moreover, cGAMP-loaded PC7A micelles (2.5 μg/50 μg polymer), i.e., ONM-501, showed a synergistic antitumor immune response in tumor-bearing mice, significantly improving long-term survival compared with either free cGAMP (2.5 μg) or empty PC7A micelles (50 μg), upon intratumoral injection [199], as well as in vitro synergistic STING activation in resected human tumors and lymph nodes [199]. Here, STING1 is linked to neoplasm.