Yang et al. modified the surface of exosomes by fusing CDX peptide (amino acid sequence: FKESWREARGTRIERG) targeting PTEN-deficient human U87 glioblastoma cells and CREKA peptide targeting PTEN-deficient mouse GL261 glioblastoma cells to the N-terminal of CD47 on the external exosomal surface. This evidence concerns the gene PTEN and glioblastoma.