After being loaded with 5-fluorouracil (5-FU) and miRNA-21 inhibitor via electroporation, this ZHER2 tagging exosomes enabled specifically co-delivery of these agents to HER2-expressing colon tumors, significantly enhancing cytotoxicity against 5-FU-resistant colon cancer cells [183]. The gene discussed is ERBB2; the disease is colonic neoplasm.