Since BAP1 (BRCA1-Associated Protein 1) and NF2 (Neurofibromin 2) are frequently mutated in mesothelioma and exploit fundamental functions in regulating cell death, proliferation, and chromatin organization [35,36,37,38,39], their expression was evaluated by immunofluorescence in MSTO-211H and Met-5a cells. This evidence concerns the gene BAP1 and mesothelioma.