Notably, anti-HER2/neu IgG3-(GM-CSF) is a full IgG ICK fused to GM-CSF that accumulated in the tumor and spleen in animal models and was able to enhance both CD4+ Th1- and Th2-mediated immune responses and reduce tumor growth in anti-HER2-resistant tumors [242]. The gene discussed is ERBB2; the disease is neoplasm.