NLRP3 and colitis: In related research, the Bacteroides dorei strain (BDX-01) and its therapeutic effects were investigated in a colitis mouse model by regulating BA metabolism, indicated by changes in total fecal BA levels and BA ratios, and by affecting the FXR-NLRP3 inflammasome signaling pathway, which led to reduced proinflammatory cytokine expression and diminished IL-1β secretion in the colon, thereby mitigating DSS-induced experimental colitis [9,147,148,149,150,151].