GSTM1 and cytomegalovirus infection: While acute hepatitis is almost the sine qua non of active CMV infection [25,27,30], it is benign and self-limited in the majority of cases, although overt jaundice (often mild) was reported in 3% of 115 immunocompetent hospitalized patients [27], and the associated inflammatory response may be severe enough to cause normocytic anemia (e.g., Hb 11 gr/dL), hypoalbuminemia (e.g., 2.9 g/L), and markedly increased ferritin levels (e.g., 2640 ng/mL) [51].