A significant difference was observed in the ROI signals captured from the mouse knee joints only at the early phase of the disease, on day 3 after infection [Figure 5C], as represented in Figure 5D. S100A8/A9 production showed no significant difference through the whole course of the disease [Figure 5E], whereas a significant difference in IL-6 levels was observed only on day 1 after infection between the groups [Figure 5F]. The gene discussed is S100A8; the disease is infection.