Exosomal Sja-miR-71a from S. japonicum eggs targets Semaphorin 4D (Sema4D), thereby inhibiting the TGF-β1/SMAD and IL-13/STAT6 pathways and regulating the Th1/Th2/Th17 and Treg balances to inhibit liver fibrosis [62]. This evidence concerns the gene SEMA4D and Hepatic fibrosis.