The genes dual-specificity tyrosine-phosphorylation-regulated kinase 1A (DYRK1A), amyloid precursor protein (APP), cystathionine beta-synthase (CBS), and E26 transformation-specific transcription factor 2 (ETS2) play crucial roles in the cognitive and developmental impairments observed in individuals with DS [9,10,11]. The gene discussed is ETS2; the disease is Dravet syndrome.